Marketing

n the United States, the FDA relaxed rules on prescription drug marketing in 1997, allowing advertisements targeted directly to consumers.[24] Lilly-ICOS hired the Grey Worldwide Agency in New York, part of the Grey Global Group, to run the Cialis advertising campaign.[25] Marketers for Cialis has taken advantage of its greater duration compared to its competitors in advertisements for the drug; Stuart Elliot of The New York Times opined: “The continuous presence of women in Cialis ads is a subtle signal that the drug makes it easier for them to set the pace with their men, in contrast to the primarily male-driven imagery for Levitra and Viagra.”[25] Iconic themes in Cialis ads include couples in bathtubs and the slogan “When the moment is right, will you be ready?”[25] Cialis ads were unique among the ED drugs in mentioning specifics of the drug.[26] As a result, Cialis ads were also the first to describe the side effects in an advertisement, as the FDA requires advertisements with specifics to mention side effects. One of the first Cialis ads aired at the 2004 Super Bowl.[26] Just weeks before the Super Bowl, the FDA required more possible side effects to be listed in the advertisement, including priapism.[26] Although many parents objected to the Cialis ad being aired during the Super Bowl, Janet Jackson‘s halftime “wardrobe malfunction” overshadowed Cialis.[26] In January 2006, the Cialis ads were tweaked, adding a doctor on screen to describe side effects and only running ads where more than 90 percent of the audience are adults, effectively ending Super Bowl ads.[24] In 2004, Lilly-ICOS, Pfizer, and GlaxoSmithKline spent a combined $373.1 million to advertise Cialis, Viagra, and Levitra respectively.[26] Cialis has sponsored many sporting events, including the America’s Cup and the PGA Tour, once being title sponsor of the PGA Tour Western Open tournament.[27]

Cost[edit]

In the United States, the wholesale cost of tadalafil as of May 2019 is US$1.91 for the 20 mg tabs and US$7.65 for the 2.5 mg tabs.[4]

While some health insurance providers cover at least part of the cost (typically limiting the number of doses covered per month), many providers, including those operating under Medicare Part D, do not cover the cost of medications prescribed for erectile dysfunction.[28][29]

In the U.K., a generic version of tadalafil became available in November 2017, reducing its price per pill, and will be available on the NHS. Additionally, Tadacip, manufactured in India by Cipla, is considerably less expensive.

References[edit]

  1. ^ “Cialis (tadalafil) Tablets, for Oral Use. Full Prescribing Information”. Lilly USA, LLC. Indianapolis, IN 46285, USA. Retrieved 5 November 2016.
  2. Jump up to:a b c d e f g h i j k “Tadalafil Monograph for Professionals”Drugs.com. American Society of Health-System Pharmacists. Retrieved 8 April 2019.
  3. Jump up to:a b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 796. ISBN 9780857113382.
  4. Jump up to:a b “NADAC as of 2019-05-15”Centers for Medicare and Medicaid Services. Retrieved 29 May 2019.
  5. ^ “The Top 300 of 2019”clincalc.com. Retrieved 22 December 2018.
  6. ^ “Pill Splitting” (PDF). Consumer Reports Health. 2010-01-25. Archived from the original (PDF) on 2008-10-08.
  7. ^ Wang Y, Bao Y, Liu J, Duan L, Cui Y (January 2018). “Tadalafil 5 mg Once Daily Improves Lower Urinary Tract Symptoms and Erectile Dysfunction: A Systematic Review and Meta-analysis”. Low Urin Tract Symptoms10 (1): 84–92. doi:10.1111/luts.12144PMID 29341503.
  8. ^ Penedones A, Alves C, Batel Marques F (2020). “Risk of nonarteritic ischaemic optic neuropathy with phosphodiesterase type 5 inhibitors: a systematic review and meta-analysis”. Acta Ophthalmol98 (1): 22–31. doi:10.1111/aos.14253PMID 31559705.
  9. ^ “FDA Announces Revisions to Labels for Cialis, Levitra and Viagra”Food and Drug Administration. 2007-10-18. Archived from the original on 2016-10-22. Retrieved 2009-09-28.
  10. ^ Sriram D. Medicinal Chemistry. Pearson Education India, 2010. p. 635.
  11. ^ Kaye K. Gaines. “Tadalafil (Cialis) and Vardenafil (Levitra) Recently Approved Drugs for Erectile Dysfunction”. Medscape.
  12. Jump up to:a b c d e f g Bischoff, E (June 2004). “Potency, selectivity, and consequences of nonselectivity of PDE inhibition”. International Journal of Impotence Research16: S11–4. doi:10.1038/sj.ijir.3901208PMID 15224129.
  13. Jump up to:a b Ervin, Keith (June 21, 1998). “Deep Pockets + Intense Research + Total Control = The Formula — Bothell Biotech Icos Keeps The Pipeline Full Of Promise”The Seattle Times. p. F1. Retrieved January 10, 2009.
  14. ^ Borthwick AD (May 2012). “2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products”. Chemical Reviews112 (7): 3641–3716. doi:10.1021/cr200398yPMID 22575049.
  15. ^ Baumann M (May 2011). “An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals”Beilstein Journal of Organic Chemistry7: 442–495. doi:10.3762/BJOC.7.57PMC 3107522PMID 21647262.
  16. ^ “FDA approves Viagra”. History.com. Retrieved 2014-11-12.
  17. ^ “Generic Levitra Availability”. Drugs.com. Retrieved 2015-06-01.
  18. ^ “FDA approves tadalafil for pulmonary arterial hypertension”. Drugs.com. Retrieved 2014-11-13.
  19. ^ Daugan A, Grondin P, Ruault C, Le Monnier de Gouville AC, Coste H, Kirilovsky J, Hyafil F, Labaudinière R (October 9, 2003). “The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 1: 5,6,11,11a-tetrahydro-1H-imidazo[1′,5′:1,6]pyrido[3,4-b]indole-1,3(2H)-dione analogues”Journal of Medicinal Chemistry46 (21): 4525–32. doi:10.1021/jm030056ePMID 14521414.
  20. ^ Richards, Rhonda (September 17, 1991). “ICOS At A Crest On Roller Coaster”. USA Today. p. 3B.
  21. ^ “Tadalafil”. Drugs.com. Retrieved February 23, 2018.
  22. ^ Revill, Jo (February 2, 2003). “Drugs giant says its new pill will pack more punch than rival Viagra”The Observer. Retrieved 2007-04-06.
  23. ^ “FDA approves Cialis to treat benign prostatic hyperplasia”. U.S. Food and Drug Administration. 2011-10-06. Archived from the original on 2017-01-18.
  24. Jump up to:a b Elliott, Stuart (January 10, 2006). “For Impotence Drugs, Less Wink-Wink”The New York Times. p. C2. Retrieved April 22, 2018.
  25. Jump up to:a b c Elliott, Stuart (April 25, 2004). “Viagra and the Battle of the Awkward Ads”. Business Day. The New York Times. p. 1. Retrieved April 22, 2018.
  26. Jump up to:a b c d e McCarthy, Shawn (March 5, 2005). “First they tried to play it safe; Ads for erectile dysfunction drug Cialis bared all – including a scary potential side effect. It was risky but it has paid off”The Globe and Mail. p. B4.
  27. ^ Loyd, Linda (July 6, 2003). “Two Pills Look to Topple Viagra’s Reign in Market; Levitra Expects Approval Next Month, Cialis Later This Year”. The Philadelphia Inquirer. p. E01.
  28. ^ Parker-Pope, Tara (August 28, 2009). “The Cost of Treating Erectile Dysfunction”New York Times. Retrieved 20 Dec 2016.
  29. ^ United Health Care (August 16, 2016). “Coverage Summary — Impotence Treatment”(PDF). United Health Care. Retrieved 20 Dec 2016.