n the United States, the FDA relaxed rules on prescription drug marketing in 1997, allowing advertisements targeted directly to consumers.[24] Lilly-ICOS hired the Grey Worldwide Agency in New York, part of the Grey Global Group, to run the Cialis advertising campaign.[25] Marketers for Cialis has taken advantage of its greater duration compared to its competitors in advertisements for the drug; Stuart Elliot of The New York Times opined: “The continuous presence of women in Cialis ads is a subtle signal that the drug makes it easier for them to set the pace with their men, in contrast to the primarily male-driven imagery for Levitra and Viagra.”[25] Iconic themes in Cialis ads include couples in bathtubs and the slogan “When the moment is right, will you be ready?”[25] Cialis ads were unique among the ED drugs in mentioning specifics of the drug.[26] As a result, Cialis ads were also the first to describe the side effects in an advertisement, as the FDA requires advertisements with specifics to mention side effects. One of the first Cialis ads aired at the 2004 Super Bowl.[26] Just weeks before the Super Bowl, the FDA required more possible side effects to be listed in the advertisement, including priapism.[26] Although many parents objected to the Cialis ad being aired during the Super Bowl, Janet Jackson‘s halftime “wardrobe malfunction” overshadowed Cialis.[26] In January 2006, the Cialis ads were tweaked, adding a doctor on screen to describe side effects and only running ads where more than 90 percent of the audience are adults, effectively ending Super Bowl ads.[24] In 2004, Lilly-ICOS, Pfizer, and GlaxoSmithKline spent a combined $373.1 million to advertise Cialis, Viagra, and Levitra respectively.[26] Cialis has sponsored many sporting events, including the America’s Cup and the PGA Tour, once being title sponsor of the PGA Tour Western Open tournament.[27]


In the United States, the wholesale cost of tadalafil as of May 2019 is US$1.91 for the 20 mg tabs and US$7.65 for the 2.5 mg tabs.[4]

While some health insurance providers cover at least part of the cost (typically limiting the number of doses covered per month), many providers, including those operating under Medicare Part D, do not cover the cost of medications prescribed for erectile dysfunction.[28][29]

In the U.K., a generic version of tadalafil became available in November 2017, reducing its price per pill, and will be available on the NHS. Additionally, Tadacip, manufactured in India by Cipla, is considerably less expensive.


  1. ^ “Cialis (tadalafil) Tablets, for Oral Use. Full Prescribing Information”. Lilly USA, LLC. Indianapolis, IN 46285, USA. Retrieved 5 November 2016.
  2. Jump up to:a b c d e f g h i j k “Tadalafil Monograph for Professionals” American Society of Health-System Pharmacists. Retrieved 8 April 2019.
  3. Jump up to:a b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 796. ISBN 9780857113382.
  4. Jump up to:a b “NADAC as of 2019-05-15”Centers for Medicare and Medicaid Services. Retrieved 29 May 2019.
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  8. ^ Penedones A, Alves C, Batel Marques F (2020). “Risk of nonarteritic ischaemic optic neuropathy with phosphodiesterase type 5 inhibitors: a systematic review and meta-analysis”. Acta Ophthalmol98 (1): 22–31. doi:10.1111/aos.14253PMID 31559705.
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  11. ^ Kaye K. Gaines. “Tadalafil (Cialis) and Vardenafil (Levitra) Recently Approved Drugs for Erectile Dysfunction”. Medscape.
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  16. ^ “FDA approves Viagra”. Retrieved 2014-11-12.
  17. ^ “Generic Levitra Availability”. Retrieved 2015-06-01.
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  20. ^ Richards, Rhonda (September 17, 1991). “ICOS At A Crest On Roller Coaster”. USA Today. p. 3B.
  21. ^ “Tadalafil”. Retrieved February 23, 2018.
  22. ^ Revill, Jo (February 2, 2003). “Drugs giant says its new pill will pack more punch than rival Viagra”The Observer. Retrieved 2007-04-06.
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